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SALT COMPOSITION-: Imatinib mesylate (400mg)

STORAGE-: Store below 30°C
INTRODUCTION

Cadinib 400mg Tablet belongs to the class of medicines known as tyrosine kinase inhibitors. It is used in the treatment of blood cancer (chronic myeloid leukaemia and Acute lymphocytic leukemia) and gastrointestinal stromal tumor.

Cadinib 400mg Tablet should be taken with food, but better to have it same time every day to get the most benefit. You should continue to take it as long as your doctor advises for it. The duration of treatment varies according to your need and response to treatment. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.

The most common side effects of this medicine include edema, nausea, vomiting, muscle cramps, musculoskeletal pain, diarrhea, rash, fatigue, and abdominal pain. Let your doctor know if you experience unexpected rapid weight gain. Your doctor may advise for regular monitoring of blood cells and liver function while you are taking this medicine. Do not drive or do anything requiring mental focus if you experience dizziness and blurry vision.

Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.

USES OF CADINIB TABLET

• Blood cancer (Chronic myeloid leukaemia)
• Blood cancer (Acute lymphocytic leukemia)
• Gastrointestinal stromal tumour

BENEFITS OF CADINIB TABLET

In Blood cancer (Chronic myeloid leukaemia)

Blood cancer, also called leukemia, is a cancer of the blood-forming tissues, that decreases the body's ability to fight infection. Cadinib 400mg Tablet kills or stops the growth of cancer cells and also prevents the multiplication of cancer cells. It is a potent and very toxic medicine and you should discuss the risks and benefits with your doctor. You should avoid drinking alcohol while having this treatment and drink plenty of water to stay hydrated.

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SIDE EFFECTS OF CADINIB TABLET

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Cadinib

• Edema (swelling)
• Nausea
• Vomiting
• Muscle cramp
• Musculoskeletal (bone, muscle or joint) pain
• Diarrhea
• Rash
• Fatigue
• Abdominal pain

HOW TO USE CADINIB TABLET

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Cadinib 400mg Tablet is to be taken with food.

HOW CADINIB TABLET WORKS

Cadinib 400mg Tablet is an anti-cancer medication. A protein enzyme, bcr-abl tyrosine kinase, responsible for the growth of abnormal proliferation of cancer cells. This medicine inhibits the proliferation and induces apoptosis (planned cell death) in bcr-abl positive cells (cancer cells). This is how it works to stop or slow the spread of cancer.

SAFETY ADVICE

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Cadinib 400mg Tablet. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

Cadinib 400mg Tablet is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.

Breastfeeding

CONSULT YOUR DOCTOR

Cadinib 400mg Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Lactating women should not breastfeed while using this drug and one month after stopping it.

Driving

UNSAFE

Cadinib 400mg Tablet may cause side effects which could affect your ability to drive.

Kidney

CAUTION

Cadinib 400mg Tablet should be used with caution in patients with kidney disease. Dose adjustment of Cadinib 400mg Tablet may be needed. Please consult your doctor.

Liver

CAUTION

Cadinib 400mg Tablet should be used with caution in patients with severe liver disease. Dose adjustment of Cadinib 400mg Tablet may be needed. Please consult your doctor.

WHAT IF YOU FORGET TO TAKE CADINIB TABLET?

If you miss a dose of Cadinib 400mg Tablet, skip it and continue with your normal schedule. Do not double the dose.

Company-: Cadila Pharmaceuticals Ltd